Article
Aven, a novel inhibitor of caspase activation, binds Bcl-xL and Apaf-1.
Molecular cell - 1 Jul 2000
Chau B N, Cheng E H, Kerr D A, Hardwick J M
Abstract excerpt
Bcl-x(L), an antiapoptotic Bcl-2 family member, is postulated to function at multiple stages in the cell death pathway. The possibility that Bcl-x(L) inhibits cell death at a late (postmitochondrial) step in the death pathway is supported by this report of a novel apoptosis inhibitor, Aven, which...
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