Article
Genetic alterations and expression pattern of CEACAM1 in colorectal adenomas and cancers.
Pathology oncology research : POR - 1 Mar 2011
Song Jae Hwi, Cao Zhang, Yoon Jung Hwan, Nam Suk Woo, Kim Su Young, Lee Jung Young, Park Won Sang
Abstract excerpt
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is expressed on epithelial cells throughout the intestinal tract and is a negative regulator of tumor cell growth, suggesting that it may function as a tumor suppressor. In this study, to determine whether the CEACAM1 is involved in colorectal tumorigenesis, we have investigated the genetic alterations, including mutations and allelic loss, of...
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