Article
Inhibition of apoptosis during development of colorectal cancer.
Cancer research - 1 May 1995
Bedi A, Pasricha P J, Akhtar A J, Barber J P, Bedi G C, Giardiello F M, Zehnbauer B A, Hamilton S R, Jones R J
Abstract excerpt
Colorectal tumorigenesis proceeds through an accumulation of specific genetic alterations. Studies of the mechanism by which these genetic changes effect malignant transformation have focused on the deregulation of cell proliferation. However, colorectal epithelial homeostasis is dependent not only on the rate of cell production but also on apoptosis, a genetically programmed process of autonomous cell death. We...
Topics
- Adenomatous Polyposis Coli
- Apoptosis
- Cell Transformation, Neoplastic
- Colon
- Colorectal Neoplasms
- Epithelial Cells
- Epithelium
- Humans
- Intestinal Mucosa
- Mutation
- Rectum