Article
Interaction of Fcp1 phosphatase with elongating RNA polymerase II holoenzyme, enzymatic mechanism of action, and genetic interaction with elongator.
The Journal of biological chemistry - 11 Feb 2005
Kong Stephanie E, Kobor Michael S, Krogan Nevan J, Somesh Baggavalli P, Søgaard T Max M, Greenblatt Jack F, Svejstrup Jesper Q
Abstract excerpt
Fcp1 de-phosphorylates the RNA polymerase II (RNAPII) C-terminal domain (CTD) in vitro, and mutation of the yeast FCP1 gene results in global transcription defects and increased CTD phosphorylation levels in vivo. Here we show that the Fcp1 protein associates with elongating RNAPII holoenzyme in vitro. Our data suggest that the association of Fcp1 with elongating polymerase results in CTD de-phosphorylation when...
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