Article
A motif shared by TFIIF and TFIIB mediates their interaction with the RNA polymerase II carboxy-terminal domain phosphatase Fcp1p in Saccharomyces cerevisiae.
Molecular and cellular biology - 1 Oct 2000
Kobor M S, Simon L D, Omichinski J, Zhong G, Archambault J, Greenblatt J
Abstract excerpt
Transcription by RNA polymerase II is accompanied by cyclic phosphorylation and dephosphorylation of the carboxy-terminal heptapeptide repeat domain (CTD) of its largest subunit. We have used deletion and point mutations in Fcp1p, a TFIIF-interacting CTD phosphatase, to show that the integrity of its BRCT domain, like that of its catalytic domain, is important for cell viability, mRNA synthesis, and CTD...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.