Article
Elongator, a multisubunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation.
Molecular cell - 1 Jan 1999
Otero G, Fellows J, Li Y, de Bizemont T, Dirac A M, Gustafsson C M, Erdjument-Bromage H, Tempst P, Svejstrup J Q
Abstract excerpt
The form of RNA polymerase II (RNAPII) engaged in transcriptional elongation was isolated. Elongating RNAPII was associated with a novel multisubunit complex, termed elongator, whose stable interaction was dependent on a hyperphosphorylated state of the RNAPII carboxy-terminal domain (CTD). A free form of elongator was also isolated, demonstrating the discrete nature of the complex, and free elongator could bind...
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