Article
Association studies of insulin receptor substrate 1 gene (IRS1) variants in type 2 diabetes samples enriched for family history and early age of onset.
Diabetes - 1 Dec 2004
Zeggini Eleftheria, Parkinson James, Halford Stephanie, Owen Katharine R, Frayling Timothy M, Walker Mark, Hitman Graham A, Levy Jonathan C, Sampson Mike J, Feskens Edith J M, Hattersley Andrew T, McCarthy Mark I
Abstract excerpt
The gene encoding insulin receptor substrate-1 (IRS1) represents a strong biological candidate for a contributory role in type 2 diabetes susceptibility. Indeed, functional studies have implicated the G971R variant, and a recent meta-analysis of 27 association studies suggested that carriage of 971R was associated with a 25% increase in disease risk. However, this association has not been evaluated in large...
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