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Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes.

Diabetes - 1 Dec 2004

Florez Jose C, Sjögren Marketa, Burtt Noël, Orho-Melander Marju, Schayer Steve, Sun Maria, Almgren Peter, Lindblad Ulf, Tuomi Tiinamaija, Gaudet Daniel, Hudson Thomas J, Daly Mark J, Ardlie Kristin G, Hirschhorn Joel N, Altshuler David, Groop Leif

Abstract excerpt

The insulin receptor substrate (IRS)-1 is an important component of the insulin signal transduction cascade. Several reports suggest that a Gly-->Arg change in codon 972 is associated with type 2 diabetes and related traits, and a recent meta-analysis reported a modest but nominally significant association with type 2 diabetes (odds ratio [OR] 1.25 in favor of carriers of the Arg allele [95% CI 1.05-1.48). To...

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Identifiers

PMID: 15561965
DOI: 10.2337/diabetes.53.12.3313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes.PMID 15561965Read ↗

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