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Article

Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes.

Diabetes - 1 Mar 2004

Eftychi Christina, Howson Joanna M M, Barratt Bryan J, Vella Adrian, Payne Felicity, Smyth Deborah J, Twells Rebecca C J, Walker Neil M, Rance Helen E, Tuomilehto-Wolf Eva, Tuomilehto Jaakko, Undlien Dag E, Rønningen Kjersti S, Guja Cristian, Ionescu-Tîirgovişte Constantin, Savage David A, Todd John A

Abstract excerpt

It has been proposed that type 1 and 2 diabetes might share common pathophysiological pathways and, to some extent, genetic background. However, to date there has been no convincing data to establish a molecular genetic link between them. We have genotyped three single nucleotide polymorphisms associated with type 2 diabetes in a large type 1 diabetic family collection of European descent: Gly972Arg in the...

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Identifiers

PMID: 14988278
DOI: 10.2337/diabetes.53.3.870

Genes

IRS1
KCNJ11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Analysis of the type 2 diabetes-associated single nucleotide polymorphisms in the genes IRS1, KCNJ11, and PPARG2 in type 1 diabetes.PMID 14988278Read ↗

IRS1, KCNJ11, PPARgamma2 and HNF-1alpha: do amino acid polymorphisms in these candidate genes support a shared aetiology between type 1 and type 2 diabetes?Semantic proximity Read ↗

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Analysis of separate and combined effects of common variation in KCNJ11 and PPARG on risk of type 2 diabetes.Semantic proximity Read ↗

Association testing of common variants in the insulin receptor substrate-1 gene (IRS1) with type 2 diabetes.Semantic proximity Read ↗

KCNJ11: Genetic Polymorphisms and Risk of Diabetes MellitusSemantic proximity Read ↗

Association testing in 9,000 people fails to confirm the association of the insulin receptor substrate-1 G972R polymorphism with type 2 diabetes.Semantic proximity Read ↗

Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes.Semantic proximity Read ↗

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Association analysis of type 2 diabetes Loci in type 1 diabetes.Semantic proximity Read ↗

Meta-analysis of the Gly482Ser variant in PPARGC1A in type 2 diabetes and related phenotypes.Semantic proximity Read ↗

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