Article
[Overproduction of agouti-protein did not affect cAMP level but increased steroidogenesis in adrenal glands under forskolin stimulation].
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova - 1 Sept 2004
Iakovlev T V, Karkaeva N R, Shevchenko A Iu, Makarova E N, Bazhan N M
Abstract excerpt
Mutation Agouti yellow (Ay) in mice Ay/a results in overproduction of agouti protein (AP), adult onset of obesity, increased corticosterone responses to restrain stress as compared with a/a mice (absence of AP). The enhanced corticosterone response in restrained Ay/a-mice compared with restrained a/a-mice occurred in result of increased adrenal reactivity to ACTH. The purpose of this work was to investigate the...
Topics
- Adenylyl Cyclases
- Adrenal Glands
- Agouti Signaling Protein
- Animals
- Colforsin
- Corticosterone
- Cyclic AMP
- Intercellular Signaling Peptides and Proteins
- Male
- Mice
- Mice, Mutant Strains
- Mutation
- Steroids
- Transcriptional Activation