Article
[Function of the hypothalamo-pituitary-adrenal system in mice with ectopic overexpression of agouti protein].
Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova - 1 Jul 2003
Karkaeva N R, Bazhan N M, Iakovleva T V, Makarova E N
Abstract excerpt
Agouti protein (AP) is known to antagonise the effects of melanocortins (ACTH, MSH) on the melanocortin receptors which participate in regulation of central and peripheral HPA links. This study aimed at estimation of effects of dominant mutation Agouti yellow (Ay-ectopic overexpression Agouti protein) on the HPA axis function in mice. Male mice of C57B1/6J strain of Ay/a- and a/a genotypes (control animals, lack...
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