Article
Overexpression of agouti protein and stress responsiveness in mice.
Physiology & behavior - 1 Jul 2001
Harris R B, Zhou J, Shi M, Redmann S, Mynatt R L, Ryan D H
Abstract excerpt
Ectopic overexpression of agouti protein, an endogenous antagonist of melanocortin receptors' linked to the beta-actin promoter (BAPa) in mice, produces a phenotype of yellow coat color, Type II diabetes, obesity and increased somatic growth. Spontaneous overexpression of agouti increases stress-induced weight loss. In these experiments, other aspects of stress responsiveness were tested in 12-week-old male...
Topics
- Adrenocorticotropic Hormone
- Agouti Signaling Protein
- Animals
- Biogenic Monoamines
- Body Weight
- Brain Chemistry
- Corticosterone
- Corticotropin-Releasing Hormone
- Eating
- Genotype
- Hypothalamus
- Intercellular Signaling Peptides and Proteins
- Male
- Organ Size
- Protein Biosynthesis
- Rats
- Restraint, Physical
- Stress, Psychological