Article
Overexpression of agouti protein and stress responsiveness in mice.
Physiology & behavior - 1 Jul 2001
Harris R B, Zhou J, Shi M, Redmann S, Mynatt R L, Ryan D H
Abstract excerpt
Ectopic overexpression of agouti protein, an endogenous antagonist of melanocortin receptors' linked to the beta-actin promoter (BAPa) in mice, produces a phenotype of yellow coat color, Type II diabetes, obesity and increased somatic growth. Spontaneous overexpression of agouti increases stress-induced weight loss. In these experiments, other aspects of stress responsiveness were tested in 12-week-old male...
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