Article
Short alleles of both GGN and CAG repeats at the exon-1 of the androgen receptor gene are associated to increased PSA staining and a higher Gleason score in human prostatic cancer.
The Journal of steroid biochemistry and molecular biology - 1 Jan 2009
Rodríguez-González Germán, Cabrera Saúl, Ramírez-Moreno Raquel, Bilbao Cristina, Díaz-Chico Juan C, Serra Lluis, Chesa Nicolás, Cabrera Juan J, Díaz-Chico B Nicolás
Abstract excerpt
The exon 1 of the human androgen receptor (AR) gene contains two length polymorphisms of CAG (polyglutamine) and GGN (polyglycine). "In vitro" experiments suggest that the larger GGN repeats provide a lower AR-protein yield, whereas the larger CAG repeats decrease the AR transcriptional activity, both decreasing the AR signalling intensity. Here we have tested such possibilities in human prostatic cancer (CaP)...
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