Article
Human glutathione peroxidase codon 198 variant increases nasopharyngeal carcinoma risk and progression.
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery - 1 Oct 2021
Laribi Ala, Aouf Sahar, Gabbouj Sallouha, Bouaouinaa Noureddine, Zakhama Abdelfattah, Harizi Hedi
Abstract excerpt
PURPOSE: Glutathione peroxidase 1 (GPx-1) is a selenium-dependent detoxifying enzyme involved in the protection of cells against oxidative damage. Some genetic association studies reported significant associations between GPx-1 Pro198Leu variant and carcinogenesis across different populations; however, the impact of this variant on nasopharyngeal carcinoma (NPC) has not been explored. Therefore, the present study...
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