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Article

Molecular consequences of genetic variations in the glutathione peroxidase 1 selenoenzyme.

Cancer research - 15 Oct 2009

Zhuo Pin, Goldberg Marci, Herman Lauren, Lee Bao-Shiang, Wang Hengbing, Brown Rhonda L, Foster Charles B, Peters Ulrike, Diamond Alan M

Abstract excerpt

Accumulating data have implicated the selenium-containing cytosolic glutathione peroxidase, GPx-1, as a determinant of cancer risk and a mediator of the chemopreventive properties of selenium. Genetic variants of GPx-1 have been shown to be associated with cancer risk for several types of malignancies. To investigate the relationship between GPx-1 enzyme activity and genotype, we measured GPx-1 enzyme activity...

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Identifiers

PMID: 19826042
DOI: 10.1158/0008-5472.CAN-09-1791
PMCID: PMC2763328

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