Article
Molecular consequences of genetic variations in the glutathione peroxidase 1 selenoenzyme.
Cancer research - 15 Oct 2009
Zhuo Pin, Goldberg Marci, Herman Lauren, Lee Bao-Shiang, Wang Hengbing, Brown Rhonda L, Foster Charles B, Peters Ulrike, Diamond Alan M
Abstract excerpt
Accumulating data have implicated the selenium-containing cytosolic glutathione peroxidase, GPx-1, as a determinant of cancer risk and a mediator of the chemopreventive properties of selenium. Genetic variants of GPx-1 have been shown to be associated with cancer risk for several types of malignancies. To investigate the relationship between GPx-1 enzyme activity and genotype, we measured GPx-1 enzyme activity...
Topics
- Alanine
- Alleles
- Antioxidants
- Breast Neoplasms
- Codon
- DNA Damage
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Genotype
- Glutathione Peroxidase
- Humans
- Leucine
- Lymphocytes