Article
Genetic variants of GPX1 and SOD2 and breast cancer risk at the Ontario site of the Breast Cancer Family Registry.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jan 2004
Knight Julia A, Onay U Venus, Wells Sean, Li Hong, Shi Ellen J Q, Andrulis Irene L, Ozcelik Hilmi
Abstract excerpt
There are several genes that code for enzymes, including various forms of superoxide dismutase and glutathione peroxidase, that protect the cell against oxidative damage that, in turn, can lead to carcinogenesis. There are a few common genetic polymorphisms in these genes that lead to altered proteins. Three that have been identified are SOD2 Val-9Ala, GPX1 Pro198Leu, and the GPX1 GCG repeat (three alleles with...
Topics
- Adult
- Aged
- Breast Neoplasms
- Case-Control Studies
- Female
- Genotype
- Glutathione Peroxidase
- Humans
- Logistic Models
- Male
- Middle Aged
- Ontario
- Postmenopause