Article
Loss of heterozygosity of the human cytosolic glutathione peroxidase I gene in lung cancer.
Carcinogenesis - 1 Dec 1994
Moscow J A, Schmidt L, Ingram D T, Gnarra J, Johnson B, Cowan K H
Abstract excerpt
The consistent deletion of 3p21 in lung cancer has led to intensive efforts to identify a lung tumor suppressor gene at this locus. We recently mapped the gene for the selenium-dependent drug-detoxifying enzyme glutathione peroxidase 1 (GPX1) to this location by in situ hybridization. We develope...
Topics
- Alleles
- Amino Acid Sequence
- Base Sequence
- Carcinoma, Non-Small-Cell Lung
- Chromosomes, Human, Pair 3
- Cytosol
- DNA Mutational Analysis
- DNA, Neoplasm
- Gene Frequency
- Genes
- Genotype
- Glutathione Peroxidase
- Humans
- In Situ Hybridization
- Lung Neoplasms
- Molecular Sequence Data
- Neoplasm Proteins
- Polymorphism, Genetic