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Article

Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes.

The Journal of biological chemistry - 18 Feb 2005

Katanosaka Yuki, Iwata Yuko, Kobayashi Yuko, Shibasaki Futoshi, Wakabayashi Shigeo, Shigekawa Munekazu

Abstract excerpt

The cardiac Na(+)/Ca(2+) exchanger (NCX1) is the predominant mechanism for the extrusion of Ca(2+) from beating cardiomyocytes. The role of protein phosphorylation in the regulation of NCX1 function in normal and diseased hearts remains unclear. In our search for proteins that interact with NCX1 using a yeast two-hybrid screen, we found that the C terminus of calcineurin Abeta, containing the autoinhibitory...

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Identifiers

PMID: 15557343
DOI: 10.1074/jbc.M410240200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Calcineurin inhibits Na+/Ca2+ exchange in phenylephrine-treated hypertrophic cardiomyocytes.PMID 15557343Read ↗

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