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Article

A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction.

The International journal of developmental biology - 1 Jan 2010

Wansleeben Carolien, Feitsma Harma, Tertoolen Leon, Kroon Carla, Guryev Victor, Cuppen Edwin, Meijlink Frits

Abstract excerpt

The biological role and structure-function relationship of the Na(+)Ca(2+) exchanger NCX1 have been the subject of much investigation. Subtle mutagenesis to study the function of a protein seems only feasible in in vitro systems, but genetic forward screens have the potential to provide in vivo models to study single amino acid substitutions. In a genetic screen in mouse, we have isolated a mutant line carrying a...

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Identifiers

PMID: 21302256
DOI: 10.1387/ijdb.093051cw

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A novel mutant allele of Ncx1: a single amino acid substitution leads to cardiac dysfunction.PMID 21302256Read ↗

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