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Article

Endothelin-1 enhances the activity of Na+/Ca2+ exchanger type 1 in renal epithelial cells.

Journal of cardiovascular pharmacology - 1 Nov 2004

Kita Satomi, Katsuragi Takeshi, Iwamoto Takahiro

Abstract excerpt

The Na+/Ca2+ exchanger, an ion transporter across the plasma membrane, is considered to play a role in calcium reabsorption in the renal nephron. We found that endothelin-1 enhanced Na+/Ca2+ exchange activity in renal epithelial LLC-PK1 cells. Treatment with endothelin-1 increased concomitantly the phosphorylation of Na+/Ca2+ exchanger type 1 (NCX1). Chelerythrine and prolonged exposure to phorbol 12-myristate...

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Identifiers

PMID: 15838289
DOI: 10.1097/01.fjc.0000166262.19852.b5

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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