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Article

Pax5-Deficient Mice Exhibit Early Onset Osteopenia with Increased Osteoclast Progenitors

1 Dec 2004

Abstract excerpt

Pax5 encodes BSAP, a member of the paired box domain transcription factors, whose expression is restricted to B lymphocyte lineage cells. Pax5(-/-) mice have a developmental arrest of the B cell lineage at the pro-B cell stage. We show here that Pax5(-/-) mice are severely osteopenic, missing 60% of their bone mass. The osteopenia can be accounted for by a >100% increase in the number of osteoclasts in bone...

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Identifiers

PMID: 15557148
DOI: 10.4049/jimmunol.173.11.6583

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