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Article

Pax5 Negatively Regulates Osteoclastogenesis through Downregulation of Blimp1.

International journal of molecular sciences - 20 Feb 2021

Yu Jiyeon, Kim Sumi, Lee Nari, Jeon Hyoeun, Lee Jun, Takami Masamichi, Rho Jaerang

Abstract excerpt

Paired box protein 5 (Pax5) is a crucial transcription factor responsible for B-cell lineage specification and commitment. In this study, we identified a negative role of Pax5 in osteoclastogenesis. The expression of Pax5 was time-dependently downregulated by receptor activator of nuclear factor kappa B (RANK) ligand (RANKL) stimulation in osteoclastogenesis. Osteoclast (OC) differentiation and bone resorption...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 33672551
DOI: 10.3390/ijms22042097
PMCID: PMC7923754

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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