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Article

Absence of sclerostin adversely affects B-cell survival.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jul 2012

Cain Corey J, Rueda Randell, McLelland Bryce, Collette Nicole M, Loots Gabriela G, Manilay Jennifer O

Abstract excerpt

Increased osteoblast activity in sclerostin-knockout (Sost(-/-)) mice results in generalized hyperostosis and bones with small bone marrow cavities resulting from hyperactive mineralizing osteoblast populations. Hematopoietic cell fate decisions are dependent on their local microenvironment, which contains osteoblast and stromal cell populations that support both hematopoietic stem cell quiescence and facilitate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 22434688
DOI: 10.1002/jbmr.1608
PMCID: PMC3377789

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of sclerostin adversely affects B-cell survival.PMID 22434688Read ↗

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Osteocyte-Derived Sclerostin Inhibits Bone Formation: Its Role in Bone Morphogenetic Protein and Wnt SignalingSemantic proximity Read ↗

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Molecular Basis for Craniofacial Phenotypes Caused by Sclerostin Deletion.Semantic proximity Read ↗

Cbfa1/RUNX2 Directs Specific Expression of the Sclerosteosis Gene (SOST)Semantic proximity Read ↗

The skeletal cell-derived molecule sclerostin drives bone marrow adipogenesis.Semantic proximity Read ↗

An Additional Lrp4 High Bone Mass Mutation Mitigates the Sost-Knockout Phenotype in Mice by Increasing Bone Remodeling.Semantic proximity Read ↗

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