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Article

Negative regulation of osteoclast precursor differentiation by CD11b and β2 integrin-B-cell lymphoma 6 signaling.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2013

Park-Min Kyung-Hyun, Lee Eun Young, Moskowitz Neal K, Lim Elisha, Lee Sun-Kyeong, Lorenzo Joseph A, Huang Chuanxin, Melnick Ari M, Purdue P Edward, Goldring Steven R, Ivashkiv Lionel B

Abstract excerpt

Negative regulation of osteoclastogenesis is important for bone homeostasis and prevention of excessive bone resorption in inflammatory and other diseases. Mechanisms that directly suppress osteoclastogenesis are not well understood. In this study we investigated regulation of osteoclast differentiation by the β2 integrin CD11b/CD18 that is expressed on myeloid lineage osteoclast precursors. CD11b-deficient mice...

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Share to CD11b Antigen
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Integrin beta3

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Share to Proto-Oncogene Proteins c-bcl-6

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Source

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Identifiers

PMID: 22893614
DOI: 10.1002/jbmr.1739
PMCID: PMC3522783

Genes

BCL6
NFATC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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