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Article

Cellular and Molecular Mechanisms of MT1-MMP-Dependent Cancer Cell Invasion

8 Aug 2016

Abstract excerpt

Metastasis is responsible for most cancer-associated deaths. Accumulating evidence based on 3D migration models has revealed a diversity of invasive migratory schemes reflecting the plasticity of tumor cells to switch between proteolytic and nonproteolytic modes of invasion. Yet, initial stages of localized regional tumor dissemination require proteolytic remodeling of the extracellular matrix to overcome tissue...

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PMID: 27501444
DOI: 10.1146/annurev-cellbio-111315-125227

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