MT-MMPs play pivotal roles in cancer dissemination.

doi:10.1023/a:1015527220537

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Article

MT-MMPs play pivotal roles in cancer dissemination.

Clinical & experimental metastasis - 1 Jan 2002

Yana Ikuo, Seiki Motoharu

Abstract excerpt

Matrix metalloproteinases (MMPs), a family of zinc-binding endopeptidases, play important roles in cancer proliferation and dissemination, and may be further associated with other diseases. In particular, membrane-type MMPs (MT-MMPs) are crucial for cancer cell invasion. In this report, we summarize the current views on the role of MT-MMPs in cancer dissemination. The regulated and restricted degradation of the...

Topics

Amino Acid Sequence
Animals
Cell Adhesion
Cells, Cultured
Endothelium, Vascular
Enzyme Activation
Extracellular Matrix
Humans
Matrix Metalloproteinase 1
Matrix Metalloproteinases, Membrane-Associated
Metalloendopeptidases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Models, Biological

Molecular Sequence Data

Neoplasms

Neovascularization, Pathologic

Phenotype

Sequence Homology, Amino Acid

Tissue Inhibitor of Metalloproteinases

Source

Open in PubMed

Identifiers

PMID: 12067201
DOI: 10.1023/a:1015527220537

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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