Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.

Nature cell biology - 1 Sept 2014

Shimoda Masayuki, Principe Simona, Jackson Hartland W, Luga Valbona, Fang Hui, Molyneux Sam D, Shao Yang W, Aiken Alison, Waterhouse Paul D, Karamboulas Christina, Hess Franz M, Ohtsuka Takashi, Okada Yasunori, Ailles Laurie, Ludwig Andreas, Wrana Jeffrey L, Kislinger Thomas, Khokha Rama

Abstract excerpt

Cancer-associated fibroblasts (CAFs) drive tumour progression, but the emergence of this cell state is poorly understood. A broad spectrum of metalloproteinases, controlled by the Timp gene family, influence the tumour microenvironment in human cancers. Here, we generate quadruple TIMP knockout (TIMPless) fibroblasts to unleash metalloproteinase activity within the tumour-stromal compartment and show that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to ADAM Proteins
Share to Amyloid Precursor Protein Secretases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exosomes

Share to Mammary Neoplasms, Experimental

Share to Metalloendopeptidases

Share to Mice, Inbred NOD

Share to Tissue Inhibitor of Metalloproteinases

Share to Tumor Burden

Source

Identifiers

PMID: 25150980
DOI: 10.1038/ncb3021

Genes

ADAM10

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of the Timp gene family is sufficient for the acquisition of the CAF-like cell state.PMID 25150980Read ↗

The TIMP protein family: diverse roles in pathophysiologySemantic proximity Read ↗

Unravelling the distinct biological functions and potential therapeutic applications of TIMP2 in cancerSemantic proximity Read ↗

The Role of Tissue Inhibitors of Metalloproteinases in Tumorigenesis and MetastasisSemantic proximity Read ↗

Whole Organism Profiling of the Timp Gene FamilySemantic proximity Read ↗

Matrix metalloproteinases at a glanceSemantic proximity Read ↗

Molecular and clinical insights of matrix metalloproteinases into cancer spread and potential therapeutic interventionsSemantic proximity Read ↗

Tumor cell traffic through the extracellular matrix is controlled by the membrane-anchored collagenase MT1-MMP.Semantic proximity Read ↗

SPARC is a new driver of early breast tumor progression via TGF-β -dependent mechanismSemantic proximity Read ↗

Extracellular Vesicles Enriched with Moonlighting Metalloproteinase Are Highly Transmissive, Pro-Tumorigenic, and Trans-Activates Cellular Communication Network Factor (CCN2/CTGF): CRISPR against CancerSemantic proximity Read ↗

Relevant MicroRNAs of MMPs and TIMPs with Certain Gut Microbiota Could Be Involved in the Invasiveness and Metastasis of Malignant TumorsSemantic proximity Read ↗

ADAM8 in invasive cancers: links to tumor progression, metastasis, and chemoresistanceSemantic proximity Read ↗

The roles of ADAMTS metalloproteinases in tumorigenesis and metastasisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.