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Article

MT1-MMP controls human mesenchymal stem cell trafficking and differentiation

9 Nov 2009

Abstract excerpt

Human mesenchymal stem cells (hMSCs) localized to bone marrow, nonhematopoietic organs, as well as perivascular niches are postulated to traffic through type I collagen-rich stromal tissues to first infiltrate sites of tissue damage, inflammation, or neoplasia and then differentiate. Nevertheless, the molecular mechanisms supporting the ability of hMSCs to remodel 3-dimensional (3D) collagenous barriers during...

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PMID: 19901267
DOI: 10.1182/blood-2009-06-228494

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