Article
A cancer cell metalloprotease triad regulates the basement membrane transmigration program.
Genes & development - 1 Oct 2006
Hotary Kevin, Li Xiao-Yan, Allen Edward, Stevens Susan L, Weiss Stephen J
Abstract excerpt
Carcinoma cells initiate the metastatic cascade by inserting invasive pseudopodia through breaches in the basement membrane (BM), a specialized barrier of cross-linked, extracellular matrix macromolecules that underlies epithelial cells and ensheaths blood vessels. While BM invasion is the sine qua non of the malignant phenotype, the molecular programs that underlie this process remain undefined. To identify...
Topics
- Animals
- Basement Membrane
- COS Cells
- Cell Line
- Cell Line, Tumor
- Cell Movement
- Chlorocebus aethiops
- Collagen Type IV
- Extracellular Matrix
- Humans
- Matrix Metalloproteinase 14