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Protein–protein interactions within the Fatty Acid Synthase‐II system of <i>Mycobacterium tuberculosis</i> are essential for mycobacterial viability

30 Sept 2004

Abstract excerpt

Despite the existence of efficient chemotherapy, tuberculosis remains a leading cause of mortality worldwide. New drugs are urgently needed to reduce the potential impact of the emergence of multidrug-resistant strains of the causative agent Mycobacterium tuberculosis (Mtb). The front-line antibiotic isoniazid (INH), and several other drugs, target the biosynthesis of mycolic acids and especially the Fatty Acid...

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PMID: 15554959
DOI: 10.1111/j.1365-2958.2004.04334.x

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