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Article

Protective effect of nonsteroidal anti-inflammatory drugs on colorectal adenomas is modified by a polymorphism in peroxisome proliferator-activated receptor delta.

Pharmacogenetics and genomics - 1 Jan 2006

Siezen Christine L E, Tijhuis Mariken J, Kram Nicolien R, van Soest Eva M, de Jong Dirk J, Fodde Riccardo, van Kranen Henk J, Kampman Ellen

Abstract excerpt

OBJECTIVE: Nonsteroidal anti-inflammatory drugs (NSAIDs) are associated with a decreased risk of colorectal tumors. Single nucleotide polymorphisms (SNPs) in target genes of NSAID action, and their haplotypes, might modulate this protective effect. METHODS: A case-control study including 724 cases and 682 controls was used to evaluate the effect of NSAIDs on colorectal adenoma risk in The Netherlands, a country...

Read the complete abstract on PubMed

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Share to Adenoma
Share to Anti-Inflammatory Agents, Non-Steroidal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Colorectal Neoplasms

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Share to Polymorphism, Single Nucleotide

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Source

Identifiers

PMID: 16344721
DOI: 10.1097/01.fpc.0000182778.03180.f3

Genes

PTGS1
PTGS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Protective effect of nonsteroidal anti-inflammatory drugs on colorectal adenomas is modified by a polymorphism in peroxisome proliferator-activated receptor delta.PMID 16344721Read ↗

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