Article
Differential protein expression profile in gastrointestinal stromal tumors.
Amino acids - 1 Dec 2004
Landuyt B, Prenen H, Debiec-Rychter M, Sciot R, de Bruijn E A, van Oosterom A T
Abstract excerpt
Gastrointestinal stromal tumors (GISTs) arise from the interstitial cells of Cajal through gain of function mutations of the oncogene KIT. Imatinib offers the first effective treatment for patients with GISTs, but the therapeutic outcome strongly depends on the type of KIT mutation. We used Prote...
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