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Article

The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status.

The American journal of pathology - 1 Jul 2004

West Robert B, Corless Christopher L, Chen Xin, Rubin Brian P, Subramanian Subbaya, Montgomery Kelli, Zhu Shirley, Ball Catherine A, Nielsen Torsten O, Patel Rajiv, Goldblum John R, Brown Patrick O, Heinrich Michael C, van de Rijn Matt

Abstract excerpt

We recently characterized gene expression patterns in gastrointestinal stromal tumors (GISTs) using cDNA microarrays, and found that the gene FLJ10261 (DOG1, discovered on GIST-1), encoding a hypothetical protein, was specifically expressed in GISTs. The immunoreactivity of a rabbit antiserum to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 15215166
DOI: 10.1016/S0002-9440(10)63279-8
PMCID: PMC1618538

Genes

KIT
PDGFRA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15215166-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status.PMID 15215166Read ↗

A novel monoclonal antibody against DOG1 is a sensitive and specific marker for gastrointestinal stromal tumors.Semantic proximity Read ↗

Mutation assay of the novel gene DOG1 in gastrointestinal stromal tumors (GISTs).Semantic proximity Read ↗

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Parallelism of DOG1 expression with recurrence risk in gastrointestinal stromal tumors bearing KIT or PDGFRA mutations.Semantic proximity Read ↗

DOG1 and PKC-θ are useful in the diagnosis of KIT-negative gastrointestinal stromal tumors.Semantic proximity Read ↗

Gastrointestinal stromal tumours – an update for histopathologistsSemantic proximity Read ↗

DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors.Semantic proximity Read ↗

Presence of PDGFRA and DOG1 mutations in gastrointestinal stromal tumors among Chinese population.Semantic proximity Read ↗

DOG1 overexpression is associated with mismatch repair deficiency and BRAF mutations but unrelated to cancer progression in colorectal cancer.Semantic proximity Read ↗

PDGFRA and KIT Mutation Status and Its Association With Clinicopathological Properties, Including DOG1.Semantic proximity Read ↗

Mapping of DOG1 expression in colorectal carcinomas.Semantic proximity Read ↗

Diagnostic significance of DOG-1 and PKC-θ expression and c-Kit/PDGFRA mutations in gastrointestinal stromal tumoursSemantic proximity Read ↗

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