Article
Differentially expressed proteins in gastrointestinal stromal tumors with KIT and PDGFRA mutations.
Proteomics - 1 Feb 2006
Kang Hyun Ju, Koh Kwi Hye, Yang Eungi, You Kwon Tae, Kim Hee Jin, Paik Young-Ki, Kim Hoguen
Abstract excerpt
Most gastrointestinal stromal tumors (GIST) have activating mutations in either KIT or PDGFRA. However, a small subset of GIST lacks either mutation. To investigate the molecular characteristics of GIST according to mutation type, protein expression profiles in 12 GIST (2 cases with PDGFRA mutations, 8 cases with KIT mutations and 2 cases lacking either mutation) were analyzed using 2-DE and MALDI-TOF-MS....
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