Article
qPCR in gastrointestinal stromal tumors: Evaluation of reference genes and expression analysis of KIT and the alternative receptor tyrosine kinases FLT3, CSF1-R, PDGFRB, MET and AXL.
BMC molecular biology - 20 Dec 2010
Fassunke Jana, Blum Marie-Christine, Schildhaus Hans-Ulrich, Zapatka Marc, Brors Benedikt, Künstlinger Helen, Büttner Reinhard, Wardelmann Eva, Merkelbach-Bruse Sabine
Abstract excerpt
BACKGROUND: Gastrointestinal stromal tumors (GIST) represent the most common mesenchymal tumors of the gastrointestinal tract. About 85% carry an activating mutation in the KIT or PDGFRA gene. Approximately 10% of GIST are so-called wild type GIST (wt-GIST) without mutations in the hot spots. In...
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