Article
Functional features of gene expression profiles differentiating gastrointestinal stromal tumours according to KIT mutations and expression.
BMC cancer - 27 Nov 2009
Ostrowski Jerzy, Polkowski Marcin, Paziewska Agnieszka, Skrzypczak Magdalena, Goryca Krzysztof, Rubel Tymon, Kokoszyñska Katarzyna, Rutkowski Piotr, Nowecki Zbigniew I, Vel Dobosz Anna Jerzak, Jarosz Dorota, Ruka Wlodzimierz, Wyrwicz Lucjan S
Abstract excerpt
BACKGROUND: Gastrointestinal stromal tumours (GISTs) represent a heterogeneous group of tumours of mesenchymal origin characterized by gain-of-function mutations in KIT or PDGFRA of the type III receptor tyrosine kinase family. Although mutations in either receptor are thought to drive an early oncogenic event through similar pathways, two previous studies reported the mutation-specific gene expression profiles....
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