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Article

Time-resolved measurement of state-specific P2X2 ion channel cytosolic gating motions.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 17 Nov 2004

Fisher James A, Girdler Gemma, Khakh Baljit S

Abstract excerpt

ATP-gated P2X2 channels undergo permeability changes through a process that is incompletely understood. In the present study, we used fluorescence resonance energy transfer (FRET) and electrophysiology to measure cytosolic gating motions in P2X2 channels as they enter a state with increased permeability. P2X2 channels underwent permeability changes with a time course that was similar to decreases in FRET between...

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Identifiers

PMID: 15548662
DOI: 10.1523/JNEUROSCI.3250-04.2004
PMCID: PMC6730295

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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