Article
Molecular dissection of cytokinesis by RNA interference in Drosophila cultured cells.
Molecular biology of the cell - 1 Jul 2002
Somma Maria Patrizia, Fasulo Barbara, Cenci Giovanni, Cundari Enrico, Gatti Maurizio
Abstract excerpt
We have used double-stranded RNA-mediated interference (RNAi) to study Drosophila cytokinesis. We show that double-stranded RNAs for anillin, acGAP, pavarotti, rho1, pebble, spaghetti squash, syntaxin1A, and twinstar all disrupt cytokinesis in S2 tissue culture cells, causing gene-specific phenotypes. Our phenotypic analyses identify genes required for different aspects of cytokinesis, such as central spindle...
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