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Article

Single-nucleotide polymorphisms in the SPARC gene are not associated with susceptibility to scleroderma.

Rheumatology (Oxford, England) - 1 Feb 2005

Lagan A L, Pantelidis P, Renzoni E A, Fonseca C, Beirne P, Taegtmeyer A B, Denton C P, Black C M, Wells A U, du Bois R M, Welsh K I

Abstract excerpt

OBJECTIVE: SPARC (secreted protein, acidic and rich in cysteine) is a matricellular protein that modulates cell-cell and cell-extracellular matrix interactions. SPARC expression is restricted mainly to sites of tissue remodelling and wound repair, and is prominent in fibrotic disorders. Single-nucleotide polymorphisms (SNPs) in the SPARC gene are reportedly linked to scleroderma in four ethnic groups: Choctaw...

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Source

Identifiers

PMID: 15546965
DOI: 10.1093/rheumatology/keh460

Genes

SPARC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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