A genetic variation located in the promoter region of the UPAR (CD87) gene is associated with the vascular complications of systemic sclerosis.

doi:10.1002/art.30101

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Article

A genetic variation located in the promoter region of the UPAR (CD87) gene is associated with the vascular complications of systemic sclerosis.

Arthritis and rheumatism - 1 Jan 2011

Manetti Mirko, Allanore Yannick, Revillod Lucile, Fatini Cinzia, Guiducci Serena, Cuomo Giovanna, Bonino Claudia, Riccieri Valeria, Bazzichi Laura, Liakouli Vasiliki, Cipriani Paola, Giacomelli Roberto, Abbate Rosanna, Bombardieri Stefano, Valesini Guido, Montecucco Carlomaurizio, Valentini Gabriele, Ibba-Manneschi Lidia, Matucci-Cerinic Marco

Abstract excerpt

OBJECTIVE: The UPAR gene encodes a pleiotropic receptor (urokinase-type plasminogen activator receptor [uPAR]) involved in fibrosis, immunity, angiogenesis, and vascular remodeling. Previous studies have implicated uPAR in systemic sclerosis (SSc) vasculopathy and impaired angiogenesis. We undertook this study to investigate whether UPAR gene promoter polymorphisms might be associated with SSc phenotypes in the...

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PMID: 20967855
DOI: 10.1002/art.30101

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