Article

SPARC regulation of PMN clearance protects from pristane induced lupus and rheumatoid arthritis

2020-08-10

Abstract excerpt

One step along the pathogenesis of Systemic lupus erythematosus (SLE) is associated with polymorphonuclear leukocyte (PMN) death and their ineffective removal by M2-macrophages. The secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein with unexpected immunosuppressive function in M2-macrophages and myeloid cells. To investigate the role of SPARC in autoimmunity, we adopted a pristane–ind...

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Literature Corpus work: e9e28780-b7aa-52d5-8a8d-d22b0853fab0
DOI: 10.1101/2020.08.10.243816

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