Article
Genome-wide association study for regions of systemic sclerosis susceptibility in a Choctaw Indian population with high disease prevalence.
Arthritis and rheumatism - 1 Sept 2003
Zhou Xiaodong, Tan Filemon K, Wang Ning, Xiong Momiao, Maghidman Samuel, Reveille John D, Milewicz Dianna M, Chakraborty Ranajit, Arnett Frank C
Abstract excerpt
OBJECTIVE: Systemic sclerosis (SSc) is a complex, multisystem connective tissue disease in which genetic factors contribute to disease susceptibility. The aim of this study was to localize chromosome regions associated with susceptibility to SSc in a relatively isolated and homogeneous population of Choctaw Indians with a high prevalence of SSc. METHODS: A genome-wide microsatellite screen at 10 cM resolution...
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