Article
Human formyl peptide receptor 1 (FPR1) c.32C>T SNP is associated with decreased soluble E-selectin levels.
Pharmacogenomics - 1 Jun 2009
Benachour Hamanou, Zaiou Mohamed, Herbeth Bernard, Lambert Daniel, Lamont John V, Pfister Michèle, Siest Gérard, Tiret Laurence, Blankenberg Stefan, Fitzgerald Peter S, Visvikis-Siest Sophie
Abstract excerpt
AIMS: The human formyl peptide receptor (FPR) is a G protein-coupled chemoattractant receptor that is thought to mediate inflammatory responses. The FPR1 gene is highly polymorphic. In a recent study, the FPR1 c.32C>T SNP, resulting in the amino-acid substitution I11T, was reported to be significantly associated with C-reactive protein levels. Therefore, this study sought to determine if the impact of such a...
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