E-selectin gene S128R polymorphism is associated with poor prognosis in patients with stage II or III colorectal cancer.

doi:10.1016/j.ejca.2009.03.011

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Article

E-selectin gene S128R polymorphism is associated with poor prognosis in patients with stage II or III colorectal cancer.

European journal of cancer (Oxford, England : 1990) - 1 Jul 2009

Hebbar Mohamed, Adenis Antoine, Révillion Françoise, Duhamel Alain, Romano Olivier, Truant Stéphanie, Libersa Christian, Giraud Claire, Triboulet Jean-Pierre, Pruvot François-René, Peyrat Jean-Philippe

Abstract excerpt

Some host-related factors may predict the risk of metastasis after surgery of colorectal cancer (CRC). The endothelial adhesion molecule E-selectin is implicated in the metastatic spread of CRC. We postulated that some polymorphisms within the E-selectin gene, especially the S128R polymorphism, may increase the risk of metastases by facilitating adhesion of tumour cells to the endothelium. We collected blood...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Colorectal Neoplasms
DNA, Neoplasm
E-Selectin
Female
Follow-Up Studies
Genotype

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Male

Middle Aged

Neoplasm Staging

P-Selectin

Polymorphism, Genetic

Prognosis

Survival Analysis

Source

Open in PubMed

Identifiers

PMID: 19361981
DOI: 10.1016/j.ejca.2009.03.011

Genes

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-19361981-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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