Article

MND1 and PSMC3IP control PARP inhibitor sensitivity in mitotic cells

2022-08-26

Abstract excerpt

The PSMC3IP-MND1 heterodimer promotes RAD51 and DMC1-dependent D-loop formation during meiosis in yeast and mammalian organisms. For this purpose, it catalyzes the DNA strand exchange activities of the recombinases. Interestingly, in a panel of genome-scale CRISPR-Cas9 mutagenesis and interference screens in mitotic cells, we found that depletion of either PSMC3IP or MND1 caused sensitivity to clinical Poly (ADP...

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Identifiers and source

Literature Corpus work: 01431bfa-fc4e-5d92-ab31-39cb5a217bc7
DOI: 10.1101/2022.08.24.505108

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