Article
Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition.
Life science alliance - 1 Feb 2020
Schukken Klaske M, Lin Yu-Chih, Bakker Petra L, Schubert Michael, Preuss Stephanie F, Simon Judith E, van den Bos Hilda, Storchova Zuzana, Colomé-Tatché Maria, Bastians Holger, Spierings Diana Cj, Foijer Floris
Abstract excerpt
Chromosomal instability (CIN) and aneuploidy are hallmarks of cancer. As most cancers are aneuploid, targeting aneuploidy or CIN may be an effective way to target a broad spectrum of cancers. Here, we perform two small molecule compound screens to identify drugs that selectively target cells that are aneuploid or exhibit a CIN phenotype. We find that aneuploid cells are much more sensitive to the energy...
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