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Article

A selection-based next generation sequencing approach to develop robust, genotype-specific mutation profiles in Saccharomyces cerevisiae.

G3 (Bethesda, Md.) - 17 Jun 2021

Lamb Natalie A, Bard Jonathan E, Buck Michael J, Surtees Jennifer A

Abstract excerpt

Distinct mutation signatures arise from environmental exposures and/or from defects in metabolic pathways that promote genome stability. The presence of a particular mutation signature can therefore predict the underlying mechanism of mutagenesis. These insults to the genome often alter dNTP pools, which itself impacts replication fidelity. Therefore, the impact of altered dNTP pools should be considered when...

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Identifiers

PMID: 33784385
DOI: 10.1093/g3journal/jkab099
PMCID: PMC8495734

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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