Article
Identification of pathways controlling DNA damage induced mutation in Saccharomyces cerevisiae.
DNA repair - 3 May 2008
Lis Ewa T, O'Neill Bryan M, Gil-Lamaignere Cristina, Chin Jodie K, Romesberg Floyd E
Abstract excerpt
Mutation in response to most types of DNA damage is thought to be mediated by the error-prone sub-branch of post-replication repair and the associated translesion synthesis polymerases. To further understand the mutagenic response to DNA damage, we screened a collection of 4848 haploid gene deletion strains of Saccharomyces cerevisiae for decreased damage-induced mutation of the CAN1 gene. Through extensive...
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