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Article

Hypermethylation of <i>RASSF1A</i> and <i>BLU</i> tumor suppressor genes in non‐small cell lung cancer: Implications for tobacco smoking during adolescence

11 Nov 2004

Abstract excerpt

The putative tumor suppressors RASSF1A and BLU are mapped adjacent to one another on chromosome 3p21.3, a region frequently deleted in lung cancer. These genes are often inactivated by promoter hypermethylation, but the association of this inactivation with clinical features of the disease or with carcinogen exposure has been poorly studied. Early age starting smoking has been hypothesized as an independent risk...

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PMID: 15540210
DOI: 10.1002/ijc.20714

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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