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Article

Inverse correlation between EGFR mutation and FHIT, RASSF1A and RUNX3 methylation in lung adenocarcinoma: relation with smoking status.

Anticancer research - 1 Apr 2011

Yanagawa Naoki, Tamura Gen, Oizumi Hiroyuki, Endoh Makoto, Sadahiro Mitsuaki, Motoyama Teiichi

Abstract excerpt

BACKGROUND: Epidemiological studies have demonstrated a causal link between tobacco smoking and lung cancer. However, lung adenocarcinoma (AC) is also frequently found in non-smokers compared with other non-small cell lung carcinoma (NSCLC) subtypes. MATERIALS AND METHODS: Mutations of both epithelial growth factor receptor (EGFR) and KRAS, and the methylation status of 10 tumor suppressor or tumor-related genes...

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Source

Identifiers

PMID: 21508367

Genes

EGFR
FHIT
KRAS
RUNX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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